Mario wakes up in a mysterious laboratory to a mysterious voice, whose owner introduces himself as Antilitus, the founder of Pato

Corp. His shifty tone puts Mario on alert; he knows he must soon find a way out of these dangerous test chambers.

Mad Science is the first installment of HansAgain's flagship series, and by far the longest. The series would go on to be recognized for it's beautiful graphics, though this one was very plain, even the alternate "HD" version.

Upon the release of SE, it would get a sequel, Bad Science, starring Luigi. Additionally, another sequel called Dementia was being developed.